Henrik Pedersen
Professor & ChairB.S., University of Rochester, 1974
M.S., Yale University, 1976
M.Phil., Yale University, 1977
Ph.D., Yale University, 1978
Tel: (732) 445-2568
Fax: (732) 445-5516
email: hpederse@sol.rutgers.edu
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Henrik PedersenProfessor & ChairB.S., University of Rochester, 1974 M.S., Yale University, 1976 M.Phil., Yale University, 1977 Ph.D., Yale University, 1978 Tel: (732) 445-2568 Fax: (732) 445-5516 email: hpederse@sol.rutgers.edu |
Plant cell culture, chemical and biochemical fiber optic sensors, applications
of biophotonics in
bioprocess technology.
| Plant cell culture is an established
technique for growing suspension cells of higher plants. Our research emphasizes
cell cultures for production of valuable chemicals and for carrying out
plant propagation though somatic embryogenesis. An overall goal is to biochemically
and genetically understand such systems and rationally manipulate them from
commercial benefit. In particular, experimental and theoretical analysis
of the California poppy plant has been extensively investigated in our labs
with emphasis on product t extraction and other techniques for redirecting
metabolite synthesis and transport. Additionally, a specific system for
the development of somatic embryos from carrot suspension cultures in small
bioreactor system has been studied and we have found that embryogenesis
is partly regulated by extracellular, proteins factors.
Chemical and biochemical sensing with fiber optic waveguides is an area
of interest in a variety of process industries. Within the diverse field
that is bioprocess technology, fermentation monitoring and control is
an area that can greatly benefit from ongoing advances in photonics researchÑthe
technology of generating and harnessing light and other forms of radiant
energy whose quantum unit is the photon. Currently, it is typical that
on-line analysis and fermentation control are carried out within the confines
of information obtained from electrochemical probes for pH and dissolve
oxygen along with a small variety of exhaust gas analyzers. Recent developments,
however, promise to greatly expand these boundaries by including the use
of new technologies employing photonics in combination with optical fibers
or imaging systems. This technology, dubbed biophotonics, has application
to non-invasive or minimally-invasive compositional analysis in a fermentation
broth as well as in associated upstream and downstream processing steps.
It is also appropriate for cell mass detection in a ferment and monitoring
of the metabolic state of cells in situ. In combination with currently
available analytical techniques, a much more robust description of the
state of bioprocesses can be obtained. This translates, in the end, to
more accurate control and more productive bioprocessing strategies for
the manufacture of pharmaceuticals, fine chemicals and the whole host
of biotechnology associated products. |
Pedersen, H., Yarmush, M.L. (1995). Dutta, A., Chin, C.-K., Pedersen, H. (1994). Byun, S.Y. and Pedersen, H. (1994). Pedersen, H., Alex, T., Chu, H.L., Chung, W-J. and Sigel, G.H. Thin
(1993). Yarmush, M.L. and Pedersen, H. (eds) . (1993). Biochemical Engineering, Current Opinion in Biotechnology 4: 181-261. Pedersen, H. Chin, C-K., and Dutta, A.. (1993). Byun, S.Y. and Pedersen, H. (1993). |