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Hong Yang
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EDUCATION Ph.D. Chemical and Biochemical Engineering 2004~present Rutgers University , New Brunswick , NJ Specialty: Metabolic Control of Hepatocyte Functions M.S. Chemical Engineering 2002 Dalian University of Technology , Dalian , China Specialty: Design for Flexibility and Operability in Process Operation Bachelor of Polymer Engineering 1999 Dalian University of Technology , Dalian , China
PROFESSIONAL EXPERIENCE Research Assistant - Rutgers University 01/05-present Develop an integrated quantitative analysis of hepatic metabolism relevant to extracorporeal bioartificial liver (BAL) devices by using metabolic engineering tools to optimize liver-specific functions Modeling and Optimization of Metabolic Network Developed a comprehensive metabolic network of liver Collaborated metabolic flux analysis with pathway analysis to make hepatocytes functional as possible, Design Approach Development and Experiment Analysis Devised a novel rational design approach to modulate an amino acid flux profile consistent with a optimal desired output Isolated and cultured rat primary hepatocytes in different culture conditions Characterized and quantified intra/extracellular metabolites using HPLC, UV/Fluorescence Spectrophotometry and metabolic flux analysis Manuscript submitted to Biotechnology and Bioengineering Cell Biology/Gene Regulation Experiment Investigated amino acid transporters characterization & kinetic activity Addressed the hormone effects on amino acid transportation Developed a novel siRNA methodology to identify alternative pathways Manuscripts in preparation
PUBLICATIONS Hong Yang, Charles M Roth, Marianthi G Ierapetritou, A Rational Design Approach for Amino Acid Supplementation in Hepatocyte Culture, Biotechnol & Bioeng, accepted Hong Yang, Charles M Roth, Marianthi G Ierapetritou, Flux and Pathway Analysis of Rat Primary Hepatocyte Cultures on Amino Acid Supplementation, in Preparation Hong Yang, Marianthi G Ierapetritou, Charles M Roth, Competition of Amino Acid Transport into Cultured Hepatocytes, in Preparation
CONFERENCES PRESENTATIONS Yang H. (Speaker), Ierapetritou MG, Roth CM, ¡°Effects of hormone and amino aid supplementation in optimal liver specific functions of hepatocytes¡±, American Institute of Chemical Engineerings (AICHE), Annual Meeting, Philadephia, PA, November 2008. Yang H. (Speaker), Ierapetritou MG, Roth CM, ¡°Optimization Analysis of Hepatic Metabolism¡±, American Institute of Chemical Engineers (AICHE), Annual Meeting, Salt Lake City, UT, November 2007. Yang H. (Speaker), Ierapetritou MG, Roth CM, ¡°Insights into Hepatic Metabolism from Flux Balance and Pathway Analyses¡±, American Institute of Chemical Engineers (AICHE), Annual Meeting, San Francisco , CA , November 2006. Ierapetritou MG (Speaker), Sharma NS, Yang H., Guzikowski SA, Yarmush ML, Roth CM, ¡°Optimization and Control of Metabolic Activities in Hepatocytes¡±, American Institute of Chemical Engineering (AICHE), Annual Meeting, Cincinnati, OH, November, 2005.
TEACHING EXPERIENCE Teaching Assistant ¨C Rutgers University Design of Separation Process, spring 2006, Chemical Engineering Kinetics, fall 2006 Participated in course development, homework/quiz/exam design and correction; Provided help to students queries by holding discuss sections; Evaluated students performances Assisted 50+ senior undergraduates on a distillation design project using CHEMCAD and kinetic design using Polymath; and Supervised a undergraduate student on research intern
AWARDS AND AFFILIATION Best Teacher Assistant, Chemical Engineering of Rutgers, rewarded by American Institute of Chemical Engineering (AICHE), New Jersey Section, 2007 Research/Teaching assistantship, Rutgers University 2004-2009 Four posters on Foundation of Systems Biology and Engineering (FOSBE), European Symposium on Computer Aided Process Engineering (ESCAPE), and Environmental Bioinformatics & Computational Toxicology Center Members of AICHE and tri-state Chinese American Chemical Society
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