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Graduate Assistant

Department of Chemical and Biochemical Engineering
Rutgers University
98 Brett Road
Piscataway, NJ 08854



Tel: 732-445-7061
Email: hongya@eden.rutgers.edu

EDUCATION

•  Ph.D. Chemical and Biochemical Engineering 2004~present

Rutgers University , New Brunswick , NJ

Specialty: Metabolic Control of Hepatocyte Functions

•  M.S. Chemical Engineering 2002

Dalian University of Technology , Dalian , China

Specialty: Design for Flexibility and Operability in Process Operation

•  Bachelor of Polymer Engineering 1999

Dalian University of Technology , Dalian , China

PROFESSIONAL EXPERIENCE

Research Assistant - Rutgers University 01/05-present

Develop an integrated quantitative analysis of hepatic metabolism relevant to extracorporeal bioartificial liver (BAL) devices by using metabolic engineering tools to optimize liver-specific functions

Modeling and Optimization of Metabolic Network

•  Developed a comprehensive metabolic network of liver

•  Collaborated metabolic flux analysis with pathway analysis to make hepatocytes functional as possible,

Design Approach Development and Experiment Analysis

•  Devised a novel rational design approach to modulate an amino acid flux profile consistent with a optimal desired output

•  Isolated and cultured rat primary hepatocytes in different culture conditions

•  Characterized and quantified intra/extracellular metabolites using HPLC, UV/Fluorescence Spectrophotometry and metabolic flux analysis

•  Manuscript submitted to Biotechnology and Bioengineering

Cell Biology/Gene Regulation Experiment

•  Investigated amino acid transporters characterization & kinetic activity

•  Addressed the hormone effects on amino acid transportation

•  Developed a novel siRNA methodology to identify alternative pathways

•  Manuscripts in preparation

PUBLICATIONS

•  Hong Yang, Charles M Roth, Marianthi G Ierapetritou, A Rational Design Approach for Amino Acid Supplementation in Hepatocyte Culture, Biotechnol & Bioeng, accepted

•  Hong Yang, Charles M Roth, Marianthi G Ierapetritou, Flux and Pathway Analysis of Rat Primary Hepatocyte Cultures on Amino Acid Supplementation, in Preparation

•  Hong Yang, Marianthi G Ierapetritou, Charles M Roth, Competition of Amino Acid Transport into Cultured Hepatocytes, in Preparation

CONFERENCES PRESENTATIONS

•  Yang H. (Speaker), Ierapetritou MG, Roth CM, “Effects of hormone and amino aid supplementation in optimal liver specific functions of hepatocytes”, American Institute of Chemical Engineerings (AICHE), Annual Meeting, Philadephia, PA, November 2008.

•  Yang H. (Speaker), Ierapetritou MG, Roth CM, “Optimization Analysis of Hepatic Metabolism”, American Institute of Chemical Engineers (AICHE), Annual Meeting, Salt Lake City, UT, November 2007.

•  Yang H. (Speaker), Ierapetritou MG, Roth CM, “Insights into Hepatic Metabolism from Flux Balance and Pathway Analyses”, American Institute of Chemical Engineers (AICHE), Annual Meeting, San Francisco , CA , November 2006.

•  Ierapetritou MG (Speaker), Sharma NS, Yang H., Guzikowski SA, Yarmush ML, Roth CM, “Optimization and Control of Metabolic Activities in Hepatocytes”, American Institute of Chemical Engineering (AICHE), Annual Meeting, Cincinnati, OH, November, 2005.

TEACHING EXPERIENCE

Teaching Assistant – Rutgers University

Design of Separation Process, spring 2006,

Chemical Engineering Kinetics, fall 2006

•  Participated in course development, homework/quiz/exam design and correction; Provided help to students queries by holding discuss sections; Evaluated students performances

•  Assisted 50+ senior undergraduates on a distillation design project using CHEMCAD and kinetic design using Polymath; and Supervised a undergraduate student on research intern

AWARDS AND AFFILIATION

•  Best Teacher Assistant, Chemical Engineering of Rutgers, rewarded by American Institute of Chemical Engineering (AICHE), New Jersey Section, 2007

•  Research/Teaching assistantship, Rutgers University 2004-2009

•  Four posters on Foundation of Systems Biology and Engineering (FOSBE), European Symposium on Computer Aided Process Engineering (ESCAPE), and Environmental Bioinformatics & Computational Toxicology Center

•  Members of AICHE and tri-state Chinese American Chemical Society

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